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We knew there would be challenges in producing the amounts we would ideally want to deliver in a short timeframe. One of these challenges is the length of time it takes to produce remdesivir. It is a linear process that requires specialized chemistry and multiple chemical reactions, some of which can take several weeks to complete. It also calls for scarce raw materials as well as sterile manufacturing capabilities with limited global capacity, which are needed to make finished vials ready for administration to patients.
Working within these parameters, our teams have found multiple ways of accelerating production. These include process improvements that cut production times. As a result,
we have reduced the end-to-end manufacturing timeline from approximately one year, to around six months. We have repurposed some of our own facilities to focus on remdesivir and we have also increased our network of external manufacturing partners around the world.